![]() Peri- and postmenopausal Malaysian women between 45 and 65 years old were invited to participate in the trial between November 2018 and December 2019 at a private tertiary hospital in Malaysia (Subang Jaya Medical Centre). The Malaysian Soy and Mammographic Density (MiSo) Study is a three-armed, randomized controlled trial with no blinding and no placebo control. ![]() Observational studies of Asian women have consistently reported that high soy intake is associated with between 14 and 41% lower relative risk of breast cancer. Studies have demonstrated that soy isoflavones may be equally as effective as hormone replacement therapy in minimizing conditions association with the menopausal transition, such as osteoporosis and somatic-vegetative symptoms. However, they exert a weaker effect compared to endogenous estrogen, and therefore, reduce estrogen exposure. ISFs are hypothesized to compete with endogenous estrogen to selectively bind to estrogen receptor sites. Soy foods are rich in isoflavones (ISFs), which are natural phytoestrogens and selective estrogen receptor modulators. Asian populations with historically lower breast cancer incidence have soy-rich diets, up to 10-fold more compared to Caucasian women. This RCT demonstrates a possible causal association between soy ISF intake and MD, a biomarker of breast cancer risk, among Asian women around the time of menopause, but these findings require confirmation in a larger trial.ĭietary interventions, such as soy intake, may be an important strategy for breast cancer risk reduction in this region. Notably, among women enrolled within 5 years of menopause dense area declined by 6 cm 2 in the ISF supplement arm, compared to <1.0 cm 2 in the control arm ( p = 0.13). The ISF supplement arm participants observed a larger decline in dense area (−1.3 cm 2), compared to the ISF diet (−0.5 cm 2) and control arm (−0.8 cm 2), though it was not statistically significant ( p = 0.48). Out of 118 women enrolled, 91 women completed the intervention, while 27 women (23%) were lost in follow up. Participants were randomized into the 100 mg/day ISF Supplement, 50 mg/day ISF Diet, or control arm, and assessed for change in absolute and relative dense area from digital mammograms conducted at enrolment and after 12 months, compared over time across study arms using Kruskal-Wallis tests. This study was registered at (NCT03686098). This three-armed RCT assessed the effects of one-year soy isoflavone (ISF) intervention on mammographic density (MD) change among healthy peri- and postmenopausal Malaysian women. Overall, Mortal Kombat Project looks to be a game you won't soon forget.Soy intake is associated with lower breast cancer risk in observational studies concerning Asian women, however, no randomized controlled trials (RCT) have been conducted among Asian women living in Asia. Also, the block systems are probably going to be a little bit different, especially since they now implement a "Grip System" where you will need to use your feet to block instead of relying on your hands. ![]() For instance, the fatalities have been completely rebuilt, so even if some of them won't make sense (as they were just cut out or modified), they will still look great. Since the game is a complete overhaul of the original, you should expect to see all the same great aspects from the original. It even has all the previous modes and fatalities included as well. There are also new characters added to the mix, as well as an entirely new game mode. The new version features a completely rewritten scripting system that ensures everything is smoother on the whole. You get to experience all the same great things the original has to offer, except you will also be enjoying a smoother and much more fluid action and movement. ![]() ![]() In fact, it could even be considered an upgrade.īasically, Mortal Kombat Project is like a brand new game in its own right. In fact, there are many new features in this version of the original that will make the entire experience much more fun than the same old boring first game. In short, it's one of the newer games on the market, but that really makes it more than worth your while. If you are looking for a new game to play on your computer, why not try Mortal Kombat Project? This is a flash based hack of the popular PlayStation 2 game developed by the now famous gamer Tameem. ![]()
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